Adipocyte apoptosis
WebTwo fundamental pathways of apoptosis are activated in adipose tissue of two dietary models of obesity and inhibition of these pathways prevents adipocyte apoptosis and … WebJul 1, 2001 · Research on adipocyte apoptosis has been limited owing to the remarkable ability of adipocytes to resist apoptosis. However, according to in vivo and in vitro evidence, the loss of mature fat...
Adipocyte apoptosis
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WebNational Center for Biotechnology Information WebMay 29, 2024 · In obese C57BL/6 mice, oral administration of T-AG17 (0.175 mg/kg for 2 weeks) lead to decreased fat accumulation and WAT hypertrophy. Further, T-AG17 induced adipocyte apoptosis by activating caspase-3. In the hepatocytes of obese mice, T-AG17 promoted an increase in the size of lipid inclusions, which was accompanied by glycogen …
WebJul 18, 2011 · Concomitantly, adipocytes undergo programmed cell death with the loss of the adipocyte-specific lipid droplet protein perilipin, and the dead/dying adipocytes are surrounded by macrophages that are organized into crown-like structures. WebApr 13, 2024 · White adipocytes store and release energy according to systemic demand, whereas brown and beige adipocytes burn energy to produce heat. Brown and beige adipocytes are characterized by a high density of mitochondria that contain uncoupling protein 1 (UCP1) in their inner membrane.
WebJan 24, 2012 · Adipocyte apoptosis is an important mechanism for regulating adipocyte cell number, and its regulation is important in obesity-combating strategies . SBM-induced apoptosis could be implicated in SBM's ability to block Akt signaling (Figure 5A) and induce TNFα expression (Figure 4C). WebMay 20, 2024 · The safe removal of apoptotic debris by macrophages—often referred to as efferocytosis—is crucial for maintaining tissue integrity and preventing self-immunity or tissue damaging inflammation. Macrophages clear tissues of hazardous materials from dying cells and ultimately adopt a pro-resolving activation state. However, adipocyte …
WebOct 12, 2024 · Adipose tissue plays a crucial role in the regulation of metabolic homeostasis through cross talk with other metabolic tissues. Adipose tissue is expanded by two processes, formation of new adipocytes (hyperplasia) and enlargement of existing adipocytes (hypertrophy) ( 1 ).
WebJan 31, 2024 · Collectively, our findings establish ColXV as a basement membrane collagen with homology to ColXVIII, indicating that it is one of the positive regulators for inducing ECM remodeling and further promoting adipocyte apoptosis. Keywords: Collagen XV; adipocytes; apoptosis; extracellular matrix remodeling; fibroblast growth factor 2. matthew storer facebookWebNov 1, 2001 · Adipocyte apoptosis is an important regulator of adipocyte number in fat depots. We have previously shown that an inhibition of protein synthesis sensitizes human adipocytes for apoptosis. In vivo ... matthew storageWebOct 27, 1997 · It is shown that human adipocytes undergo apoptosis following growth factor deprivation or mild heat injury in vitro, thus demonstrating a cellular mechanism by which normal adipocyte loss could occur in vivo. 96 Tumor necrosis factor-alpha and its second messenger, ceramide, stimulate apoptosis in cultured ovarian follicles. heresy denying the trinityWebSep 24, 2024 · Adipocytes were cultured in vitro, and a diet-induced obesity (diet-induced obesity) rat model was established to explore the effects of apelin-13 on Bcl-2 and caspase-3 factors in vivo and in vitro and its influence on the apoptosis of adipocytes. The specific report is as follows. 2. Materials and Methods 2.1. Cell Culture matthews top of the hill daly cityWebApoptosis (from Ancient Greek: ἀπόπτωσις, romanized : apóptōsis, lit. 'falling off') is a form of programmed cell death that occurs in multicellular organisms. [1] Biochemical events lead to characteristic cell changes ( … matthew stonestreet wvWebApr 12, 2024 · Adipocyte is a fully open access, multi-disciplinary journal that publishes research on all aspects of adipose tissue physiology and pathophysiology. Recognizing … matthew store up treasures in heavenWebJan 6, 2012 · Adipocytes could be removed through apoptotic mechanisms in some pathological conditions, such as in patients with tumor cachexia and HIV-infected … matthew store fixtures