Cisplatin pathway

Author: dzlt

August undefined, 2024

WebMar 20, 2024 · Cisplatin (CDDP) is a platinum-based antitumor drug [ 1 ]. Its widespread use in the treatment of breast cancer, ovarian cancer, and other cancers has greatly improved the survival rate of patients [ 1 – 4 ]. However, this process is often accompanied by serious side effects, including nephrotoxicity and ototoxicity [ 5 ]. WebCisplatin (CP), cis-diamminedichloroplatinum(II), is a potent anti-tumor agent extensively used in cancer therapy, but its frequent application leads to the development of …

Mechanisms of Cisplatin-Induced Apoptosis and of Cisplatin …

WebApr 11, 2024 · Cisplatin is a widely used chemotherapeutic agent for treatment of various cancers. However, treatment with cisplatin is associated with drug resistance and … WebApr 11, 2024 · Cisplatin is a widely used chemotherapeutic agent for treatment of various cancers. However, treatment with cisplatin is associated with drug resistance … chip iphone backup extractor

Inhibiting DNA methylation alleviates cisplatin-induced hearing …

WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin … WebNov 20, 2014 · The findings show that when activated, the STING pathway triggers a natural immune response against the tumor. This includes production of chemical signals that help the immune system identify tumor cells and generate specific killer T cells. WebCisplatin, a chemotherapy drug, is best known for curing testicular cancer. It is also used in the treatment of a wide range of other cancers, including lung, bladder, cervical, and ovarian cancers. Cisplatin and … grants available for primary schools

Enhanced Cisplatin Cytotoxicity by Disturbing the Nucleotide …

Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3

WebCisplatin (DDP) is a common therapeutic option for non‐small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying … WebApr 28, 2006 · The FA/BRCA pathway regulates the cellular response to cisplatin and other DNA cross-linking agents ( 16 ). The pathway is governed by the coordinate activity of several FA proteins. In response to cross-linkers, a protein complex composed of at least eight FA proteins (A, B, C, E, F, G, L, M) monoubiquitinates the FANCD2 protein ( 17 – 19 ). chip irfanview 32WebAug 17, 2024 · Cardiovascular complications are a well-documented limitation of conventional cancer chemotherapy. As a notable side effect of cisplatin, cardiotoxicity … chipirones english

"WebMar 15, 2024 · - Gemcitabine and cisplatin for metastatic urothelial cancer - Dose-dense MVAC chemotherapy for urothelial carcinoma - Paclitaxel, gemcitabine, and ... Ramucirumab – The combination of the VEGF pathway inhibitor ramucirumab plus docetaxel does not have an established treatment role in those with urothelial carcinoma … " - Cisplatin pathway

Cisplatin pathway

Cisplatin: mode of cytotoxic action and molecular …

WebMar 25, 2024 · Furthermore, RRS1 also induces apoptosis resistance in breast cancer cells through the ERK/Bcl-2/BAX signaling pathway. Our study is the first to show that RRS1 sensitizes breast cancer cells to cisplatin by binding to AEG-1, and it provides a theoretical basis to improve the efficacy of cisplatin-based chemotherapy.

Did you know?

WebEffects of siRNA-GLUT-1 and LY294002 on apoptosis and cell cycle in Hep-2 cells after treatment with cisplatinBefore the cisplatin treatment, the apoptotic rates of cells in the siRNA-GLUT-1 and LY294002 groups were increased markedly at 24 hours and 48 hours compared with the Hep-2 cell and siRNA-NC groups (P<0.05; Figure 2).The early … WebMar 1, 2024 · Cisplatin represents a potent chemotherapeutic molecule with wide use in a broad spectrum of malignant diseases1. Unfortunately, ototoxicity, neurotoxicity, and nephrotoxicity are serious undesirable effects of cisplatin that quite limit its application2.

WebDec 17, 2024 · In cisplatin-induced acute kidney injury (AKI) or nephrotoxicity, autophagy is rapidly induced in renal tubular epithelial cells and acts as a cytoprotective mechanism for cell survival. Both mTOR and AMPK have been implicated in the regulation of autophagy in cisplatin-induced AKI. WebAug 17, 2024 · Cisplatin (cis-Diaminodichloroplatinum, CDDP), one of the most potent chemotherapeutic agents, has been proven effective against various solid tumors, including sarcoma, soft tissue cancer, bone cancer, muscle cancer, and vascular cancer.

WebApr 15, 2024 · A 64-year-old man exhibited lack of efficacy during treatment with pirarubicin, gemcitabine and cisplatin for metastatic, high-grade non-muscle invasive bladder … National Center for Biotechnology Information www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

WebLy3214996, an inhibitor of ERK signal pathway, was administered to assess the effects of BANCR overexpression on gastric cancer cell with cisplatin-treated resistance. …

WebSep 18, 2024 · National Center for Biotechnology Information grants available for schoolWebMar 22, 2024 · We found that PRDX1 enhanced autophagy by activating the PTEN (phosphatase and tensin homolog)-AKT/protein kinase B signaling pathway in SGNs that were incubated with cisplatin, and the activation of autophagy protected SGNs against cisplatin-induced damage by reducing oxidative stress and apoptosis in SGNs. Results chipirones in englishWebCisplatin-induced DNA lesions and repair mechanisms. A) The nucleotide excision repair (NER) pathway is responsible for removing cisplatin-induced DNA adducts (such as 1,2 … chipi robot therapistWebDriving Directions to Tulsa, OK including road conditions, live traffic updates, and reviews of local businesses along the way. grants available for small charitiesWebMar 15, 2003 · In an effort to overcome the cisplatin resistance problem in ovarian cancer treatment, we have sought to enhance cisplatin cytotoxicity by perturbing the nucleotide excision repair (NER) pathway. The NER pathway is responsible for … chipirones orlyWebApr 4, 2010 · Cisplatin (cis-diamminedichloroplatinum), a platinum compound, has been an important chemotherapeutic drug for the treatment of many cancers, including ovarian, lung, testicular, and bladder cancers, as a single agent or … grants available for truck driving schoolsWebCisplatin is the most important and efficacious chemotherapeutic agent for the treatment of advanced gastric cancer. Cisplatin forms inter- and intrastrand crosslinked DNA adducts … chip iptv