Cystine slc7a11
WebThe cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is … WebSLC7A11 (also known as XCT) is a member of a hetromeric, sodium-independent, anionic amino acid transport system. It is highly specific for cysteine and glutamate. SLC7A11 is …
Cystine slc7a11
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Web★ SLC7A11&SLC3A2 蛋白具有天然 ... Parker J L, Deme J C, Kolokouris D, et al. Molecular basis for redox control by the human cystine/glutamate antiporter system xc−[J]. Nature … Cystine/glutamate transporter is an antiporter that in humans is encoded by the SLC7A11 gene. The SLC7A11 gene codes for a sodium-independent cystine-glutamate antiporter that is chloride dependent, known as system Xc- or xCT. It regulates synaptic activity by stimulating extrasynaptic receptors and performs nonvesicular glut…
WebSLC7A11: Name solute carrier family 7 member 11: Synonyms ... cystine/glutamate exchanger cystine/glutamate transporter cystine/glutamate transporter-like ... WebApr 26, 2024 · SLC7A11 encodes the antiporter xCT that imports cystine, the oxidized dimer and main source of intracellular cysteine, and exports glutamate. Targeting xCT …
WebApr 12, 2024 · SLC7A11 and solute carrier family 3 member 2 (SLC3A2) constitute system Xc- together on the cell membrane, which exports glutamate and imports cystine at a 1:1 ratio. Cystine is rapidly transformed into cysteine intracellularly, the rate-limiting amino acid for the synthesis of GSH.
WebMar 21, 2024 · SLC7A11 (Solute Carrier Family 7 Member 11) is a Protein Coding gene. Diseases associated with SLC7A11 include Cystinuria and Lysinuric Protein Intolerance . Among its related pathways are Nuclear …
WebApr 3, 2024 · Inhibit cystine importer SLC7A11/xCT and lead to depletion of GSH bank and oxidative stress-dependent cell death: Typhaneoside: AML: Induce autophagy by promoting the activation of the AMPK signal pathway and then increase the labile iron pool and promote the accumulation of cellular ROS: hopper weight calculatorWebOct 1, 2024 · The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is … look at this photograph nickelbackWebJan 2, 2024 · Amino acid transporters characterized by xCT (SLC7A11), ASCT2 (SLC1A5), and LAT1 (SLC7A5) function in the uptake and export of amino acids such as cystine and glutamine, thereby regulating glutathione synthesis, autophagy, and glutaminolysis. look at this photograph templateWebApr 18, 2024 · Among these, solute carrier family 7 member 11 ( Slc7a11; also commonly referred to as xCT) was of interest due to its known role in redox regulation through GSH biosynthesis. look at this pngWebApr 7, 2024 · 而SLC7A11&SLC3A2的表达下调,会影响Xc系统(一种专用的胱氨酸转运器),导致肿瘤细胞通过Janus激酶(JAK)信号发生铁中毒,使其成为抗癌疗法的一个聚焦靶点。. ACROBiosystems百普赛斯凭借“膜杰作”多次跨膜靶点蛋白开发技术平台,现推出由膜蛋白-VLP平台开发 ... look at this placeWebThe Cystine Analog (CA) in this kit can be taken up into cells via xCT, and the incorporated CA can be specifically detected using the Fluorescent Probe and Reducing Agent. ... L. Cao, K. Han, H. Zhang, J. Cui, X. Ma, S. Zhao, C. Zhao, S. Yin, L. Fan, H. Hu, "Patulin disrupts SLC7A11-cystine-cysteine-GSH antioxidant system and promotes renal ... look at this roofWeb与slc7a11在其他压力条件下已确立的促生存作用相反,在此我们报告了一个出乎意料的发现,即slc7a11过表达增强了癌细胞对葡萄糖的依赖性,并使癌细胞对葡萄糖饥饿诱导的细胞死亡更加敏感,相反,slc7a11缺乏则通过敲低或药理学抑制作用促进葡萄糖饥饿时癌 ... look at this public service advertisement