Glgc gwas

Author: mrrd

August undefined, 2024

WebTo generate instrument variables for lipid-lowering drug targets, we obtained summary statistics from a GWAS of LDL-C conducted by the Global Lipid Genetics Consortium (GLGC) . Participants of European ancestry from 23 studies ( N = 94,595) were genotyped with customized GWAS chips and individuals from 37 studies ( N = 93,982) were … WebWe first performed a GWAS including a discovery phase in MVP and a replication phase in the Global Lipids Genetics Consortium (GLGC) (Fig. 1). In the discovery phase (Stage …

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WebVariant set derived from blood-lipid GWAS results from GLGC and HUNT consortium Integrated transcript- and variant-level functional annotations via Ensembl Variant Effect Predictor WebApr 27, 2024 · We also evaluated the effects of lipid concentrations on AAD. Summary statistics from the Global Lipids Genetics Consortium (GLGC) GWAS, which identified more than one hundred lipid-associated loci, were applied in the present study (42, 43). The “high cholesterol” GWAS included 55,265 cases and 396,999 controls. The “Disorders of ... good animals to paint

Global Lipids Genetics Consortium Results (2013)

Web本期我们对GWAS分析做一些简单介绍。GWAS，全称genome-wide association study，即全基因组关联分析。GWAS是一种用于识别遗传区域（基因座）和性状（包括疾病）之 … WebMar 11, 2024 · Genetic association estimates for LDL-c were obtained from a meta-analysis of genome-wide association studies (GWAS) conducted by the Global Lipids Genetics Consortium (GLGC). 19 The meta-analysis was restricted to participants of European ancestry, and most contributing cohorts measured blood lipid levels after 8 or more hours … http://csg.sph.umich.edu/willer/public/lipids2013/ good animals to have as pets

xQTLbiolinks: Integrative Analysis of Quantitative Trait Locus …

PheGWAS: A new dimension to visualize GWAS across …

Web6 fetchContentEbi Examples gencodeGeneInfo <- extractGeneInfo(gencodeGeneInfoAllGranges) fetchContent Fetch data using url by three methods Description WebMar 15, 2024 · Governmentwide Acquisition Contract Dashboards. The GWAC program has taken its data to the next level by creating an interactive tool that allows GWAC … good animals to researchWeb(1) Mapping of GLGC GWAS Meta-analysis SNPs to Genes—The GLGC GWAS meta-analyses data is based on 46 lipid/lipoprotein GWAS involving over 100,000 individuals of European descent as ascertained in the United States, Europe, or Australia (16). The GLGC consortium contributed genome wide analysis data for analyses, healthier place healthier future

"WebSep 27, 2024 · The first step of this study was to pick out m 6 A-SNPs from the GLGC GWAS data set which contained 2.6 million SNPs according to the annotation information of the 313,000 m 6 A-SNPs in the... " - Glgc gwas

Glgc gwas

WebStaff Directory Members By Category/Department; Name Title Email Address Phone; Jeremy Sheetinger: Head Coach [email protected]: 678-407-5761 678-407-5761: Evan … WebJul 8, 2024 · Results: PheGWAS is demonstrated using data from Global Lipids Gene tics Consortium (GLGC) GWAS across multiple lipid traits. For single trait matching, PheGWAS highlighted all eighty -eight loci, seventy-two genes and sixty-three SNPs matched in the GLGC data. For multiple trait matching, sixty -eight of sixty-nine loci were detected,

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WebLipid GWAS summary statistics were obtained from the Million Veteran Program (MVP) (up to 215,551 European individuals) [22] and the Global Lipids Genetics Consortium (GLGC) (up to 188,577 genotyped individuals) [12]. As additional exposures in multivariable MR analyses, we used BMI summary statistics from a meta-analysis of GWASs in up to ... WebGlobal Lipids Genetics Consortium (GLGC) Low Density Lipoprotein Cholesterol Willer (2013) 96% European ancestry ieu-a-300 mg/dl Coronary Artery Disease CARDIoGRAMplusC4D ... #NAFLD GWAS Dataset by Graham et al. (discovery dataset). Power (NAFLDǂ) ǂ NAFLD GWAS Dataset by Anstee et al. (replication dataset). 0.656 …

WebUsing GWAS and comorbidity data, we present a network-based approach to predict candidate genes for lipid and lipoprotein traits. We apply a prediction pipeline incorporating interactome, co-expression, and comorbidity data to Global Lipids Genetics Consortium (GLGC) GWAS for four traits of interest, identifying phenotypically coherent modules. http://lipidgenetics.org/

WebNov 13, 2024 · Upload and share GWAS results with my.locuszoom.org ~ October 14, 2024 We are happy to announce the newest stage in our efforts to support interactive, exploratory GWAS plots: the new my.locuszoom.org upload-to-plot service. This new service generates fully interactive plots, with no limits on the number of loci you can explore.

WebFeb 9, 2024 · To mimic the GLGC test set which consisted of European cohorts, we randomly sampled 19,840 individuals from 276,791 unrelated individuals of white British ancestry in the UK BioBank

WebJun 30, 2024 · The replication rates are high for all four methods: among the significant genes identified in the GLGC GWAS, 161 out of 200 (81%), 79 out of 108 (73%), 93 out of 120 (77%), and 52 out of 69 (75%) were … good animals to write aboutWebApr 11, 2024 · A genome-wide association study (abbreviated GWAS) is a research approach used to identify genomic variants that are statistically associated with a risk for a disease or a particular trait. The method involves surveying the genomes of many people, looking for genomic variants that occur more frequently in those with a specific disease … healthier placto eat near mehttp://locuszoom.sph.umich.edu/ healthier planetWebThe GLGC lipid GWAS summary data. We used the HDL and LDL GWAS summary statistics generated by the GLGC as the validation data for the findings from the UKB individual-level GWAS data. The number of SNPs is around 2 450 000. Methods: TWAS and Extensions GE imputation models. good animals to write a poem aboutWebJun 17, 2024 · Extended Data Fig. 7 shows the number of Bonferroni-significant SNPs overlapping between lipid GWAS (eMERGE, GERA, GLGC and UKB) and lipid-guided PheWAS (eMERGE and UKB). good animated christmas moviesWebMar 29, 2024 · Fifth, the GLGC GWAS used to select instruments for plasma TG levels in discovery had accounted for lipid-lowering treatment, while the UKB GWAS used in replication had not. Last, we acknowledge that this study was restricted to populations of European ancestry, limiting the generalizability of our findings. healthier place to eatWebOct 26, 2024 · Additional information regarding the GWAS data (consortium, study cohort, and author information of the GWAS for the exposure and neuropsychiatric outcomes) are located in Table S1. We performed cis ‐instrumentation of genetically predisposed PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibition in several complementary data sets. healthier podiatry